Objectives To compare patient and physician global assessment of disease activity in patients with systemic lupus erythematosus (SLE) depending on disease duration.
Methods In performed case-control study were included patients that fulfilled SLICC classification criteria, 2012. The research included two groups: patients with early SLE – first group (disease duration less than 24 months) and non-early SLE – second group (disease duration more than 24 months). Patient and physician global assessments (PGA and PhGA) were rated by 0 -100 numeric scale. We evaluated the concordance of PGA and PhGA in each group and compared the results between groups.
Results A total of 72 SLE patients were analyzed. First group included 36 patients with a mean age 37.2±13.2 (range 18–67) years, 83.3% female and mean disease duration was 12±9.4 months. Mean PGA value were lower compared to PhGA values in this group (47.5±22.0 versus 49.1±21.0), but the difference wasn't statistically significant (p>0,05). The second group included also 36 patients, mean age was 43±10.6 (range 24–73) years, 91.7% female and mean disease duration was 120±50 months. Mean PGA value was also lower than mean PhGA in this group, but with a smaller discrepancy (50.0±19.7 versus 50.2±20.9, p>0,01). The comparison of groups showed that in patients with early SLE the discordance between PGA and PhGA, is more important than in patients with longer disease duration.
Conclusions The comparison of PGA and PhGA in patients with early SLE patients and ones with longer disease duration showed that patients early in disease duration tend to diminish PGA underestimating their general estate, but without statistically significant difference. In longer disease duration PGA and PhGA variables become similar, that suggest the patient's better understanding of their disease and general estate.
Disclosure of Interest None declared
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