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SAT0287 Ethnic Differences Strongly Influence The Phenotypic Expression of Primary Sjögren: Study of 7887 Patients from 20 Countries on 5 Continents (EULAR-SS Task Force Big Data Sjögren Project)
  1. P. Brito-Zerόn1,
  2. N. Acar-Denizli2,
  3. M. Zeher3,
  4. A. Rasmussen4,
  5. R. Seror5,
  6. T. Mandl6,
  7. X. Li7,
  8. C. Baldini8,
  9. J.-E. Gottenberg9,
  10. D. Danda10,
  11. L. Quartuccio11,
  12. R. Priori12,
  13. G. Hernández-Molina13,
  14. A. Kruize14,
  15. V. Valim15,
  16. M. Kvarnstrom16,
  17. D. Sene17,
  18. R. Gerli18,
  19. S. Praprotnik19,
  20. D. Isenberg20,
  21. R. Solans21,
  22. M. Rischmueller22,
  23. S.-H. Park23,
  24. G. Nordmark24,
  25. Y. Suzuki25,
  26. R. Giacomelli26,
  27. A. Saraux27,
  28. M. Bombardieri28,
  29. B. Hofauer29,
  30. H. Bootsma30,
  31. D. Hammenfors31,
  32. G. Fraile32,
  33. S. Carsons33,
  34. T. Gheita34,
  35. J. Morel35,
  36. C. Vollenveider36,
  37. F. Atzeni37,
  38. S. Retamozo38,
  39. I.-F. Horvath3,
  40. K. Sivils4,
  41. E. Theander6,
  42. P. Sandhya10,
  43. S. De Vita11,
  44. J. Sanchez-Guerrero13,
  45. E. van der Heijden14,
  46. V. Moça-Trevisano39,
  47. M. Wahren-Herlenius16,
  48. X. Mariette5,
  49. M. Ramos-Casals1
  1. 1Hospital Clinic, Barcelona, Spain
  2. 2Mimar Sinan Univ, Istanbul, Turkey
  3. 3Debrecen Univ, Debrecen, Hungary
  4. 4OMRF, Oklahoma, United States
  5. 5Paris-Sud Univ, Paris, France
  6. 6Lund Univ, Malmö, Sweden
  7. 7Anhui Hosp, Hefei, China
  8. 8Rheumatol Clinic, Pisa, Italy
  9. 9Strasbourg Univ, Strasbourg, France
  10. 10Christian Med Coll, Vellore, India
  11. 11Santa Maria Misericordia Hosp, Udine
  12. 12Sapienza Univ, Roma, Italy
  13. 13INNSZ, Mexico City, Mexico
  14. 14UMCU, Utrecht, Netherlands
  15. 15Espírito Santo Univ, Vitόria, Brazil
  16. 16Karolinska Univ Hosp, Stockholm, Sweden
  17. 17Lariboisière Hosp, Paris, France
  18. 18Perugia Univ, Perugia, Italy
  19. 19Clinical Center Univ, Ljubljana, Slovenia
  20. 20Univ College, London, United Kingdom
  21. 21Vall Hebron Hosp, Barcelona, Spain
  22. 22Queen Elizabeth Hosp, Woodville, Australia
  23. 23Catholic Univ, Seoul, Korea, Republic Of
  24. 24Uppsala Univ, Upssala, Norway
  25. 25Kanazawa Univ, Kanazawa, Japan
  26. 26L'Aquila Univ, L'Aquila, Italy
  27. 27Brest Univ Hosp, Brest, France
  28. 28QMUL, London, United Kingdom
  29. 29Rechts der Isar Hosp, Munich, Germany
  30. 30Groningen Univ, Groningen, Netherlands
  31. 31Haukeland Hosp, Bergen, Norway
  32. 32Ramon Cajal Hosp, Madrid, Spain
  33. 33Stony Brook Univ, Mineola, United States
  34. 34Cairo Univ, Cairo, Egypt
  35. 35Montpellier Hosp, Montpellier, France
  36. 36German Hosp, Buenos Aires, Argentina
  37. 37L. Sacco Univ, Milan, Italy
  38. 38Privado Hosp, Cόrdoba, Argentina
  39. 39Sao Paulo Federal Univ, Sao Paulo, Brazil


Objectives To analyse the influence of ethnicity on the clinical presentation at diagnosis in an international cohort of patients with primary Sjögren syndrome (pSS).

Methods The Big Data Sjögren Project is a multicentre registry formed by international experts from the EULAR-SS Task Force. By January 2016, the database included 8315 consecutive patients fulfilling the 2002 AE criteria (20 countries, 5 continents). Ethnicity was classified according to FDA (White=W, Black/African American=B, Asian=A, Hispanic=H, Others=O).

Results Ethnicity data was available in 7887 (95%) patients: 6177 W (78%), 1066 A (13%), 393 H (5%), 104 B (1%) and 147 O (2%). European patients were overwhelmingly white compared with Americans (96% vs 52%, p<0.001). The greatest differences between ethnicities (p<0.001) were observed for mean age at diagnosis (47yrs in B vs 54yrs in W), and the frequency of males (12% in B vs 4% in A), dry eyes (76% in A vs 98% in O), dry mouth (83% in A vs 99% in O), abnormal ocular tests (79% in O vs 90% in H), abnormal oral tests (65% in O vs 91% in H), positive minor salivary biopsy (75% in O vs 95% in H), positive anti-Ro (54% in O vs 84% in A) and positive anti-La (28% in O vs 50% in A).

Conclusions White patients had the oldest age at diagnosis, Black/African Americans the highest frequency of men and the lowest mean age, Asians the highest frequency of women, the lowest frequency of sicca symptoms and the highest frequency of Ro/La and Hispanics the highest frequency of abnormal diagnostic tests. Ethnicity plays a capital role in the phenotypic expression at diagnosis of primary SS.

Disclosure of Interest None declared

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