Objectives To analyse the influence of ethnicity on the clinical presentation at diagnosis in an international cohort of patients with primary Sjögren syndrome (pSS).
Methods The Big Data Sjögren Project is a multicentre registry formed by international experts from the EULAR-SS Task Force. By January 2016, the database included 8315 consecutive patients fulfilling the 2002 AE criteria (20 countries, 5 continents). Ethnicity was classified according to FDA (White=W, Black/African American=B, Asian=A, Hispanic=H, Others=O).
Results Ethnicity data was available in 7887 (95%) patients: 6177 W (78%), 1066 A (13%), 393 H (5%), 104 B (1%) and 147 O (2%). European patients were overwhelmingly white compared with Americans (96% vs 52%, p<0.001). The greatest differences between ethnicities (p<0.001) were observed for mean age at diagnosis (47yrs in B vs 54yrs in W), and the frequency of males (12% in B vs 4% in A), dry eyes (76% in A vs 98% in O), dry mouth (83% in A vs 99% in O), abnormal ocular tests (79% in O vs 90% in H), abnormal oral tests (65% in O vs 91% in H), positive minor salivary biopsy (75% in O vs 95% in H), positive anti-Ro (54% in O vs 84% in A) and positive anti-La (28% in O vs 50% in A).
Conclusions White patients had the oldest age at diagnosis, Black/African Americans the highest frequency of men and the lowest mean age, Asians the highest frequency of women, the lowest frequency of sicca symptoms and the highest frequency of Ro/La and Hispanics the highest frequency of abnormal diagnostic tests. Ethnicity plays a capital role in the phenotypic expression at diagnosis of primary SS.
Disclosure of Interest None declared
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