Objectives Researchers continue to gather evidence that transient receptor potential vanilloid (TRPV) channels contribute towards pain signaling pathways. However, it is unknown whether polymorphisms of the TRPV gene are associated with fibromyalgia (FM). For the first time, we investigated the association between the polymorphisms of the TRPV2 and TRPV3 genes with FM susceptibility and the severity of the symptoms.
Methods A total of 409 patients with FM and 423 controls were enrolled from 10 medical centers that participated in the Korean nationwide FM survey. The alleles and genotypes at three positions [rs3813768 (C>G), rs8121 (C>T), and rs1129235 (C>A)] in the TRPV2 gene, and two positions [rs7216486 (G>A) and rs395357 (C>T)] in the TRPV3 gene, were genotyped.
Results The frequencies of the alleles and genotypes of individual TRPV2 and TRPV3 genes were not significantly associated with FM susceptibility. However, the GTA haplotype of TRPV2 showed a defense against FM susceptibility (P=0.035). In addition, polymorphisms of TRPV3 were associated with symptom severity in FM patients. The single nucleotide polymorphism (SNP) rs395357 of TRPV3 was associated with the scores of the Brief Fatigue Inventory (BFI) (P=0.017) in FM patients. Furthermore, haplotypes of TRPV3 were associated with the BFI and the SF-36 mental health summary scores (P=0.036, respectively)
Conclusions This study was the first to evaluate the associations of TRPV gene polymorphisms with FM. Our results suggest that certain TRPV2 haplotypes may have a protective role against FM, and also that some genotypes and haplotypes of TRPV3 contribute towards the symptoms of FM.
Disclosure of Interest None declared
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