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THU0352 Worldwide Heterogeneous Diagnostic Approach To Primary Sjögren Syndrome in 8315 Patients (EULAR-SS Task Force Big Data Sjögren Project)
  1. P. Brito-Zeron1,
  2. N. Acar-Denizli2,
  3. M. Zeher3,
  4. A. Rasmussen4,
  5. R. Seror5,
  6. T. Mandl6,
  7. X. Li7,
  8. C. Baldini8,
  9. J.-E. Gottenberg9,
  10. D. Danda10,
  11. L. Quartuccio11,
  12. R. Priori12,
  13. G. Hernández-Molina13,
  14. A. Kruize14,
  15. V. Valim15,
  16. M. Kvarnstrom16,
  17. D. Sene17,
  18. E. Bartoloni18,
  19. S. Praprotnik19,
  20. D. Isenberg20,
  21. R. Solans21,
  22. M. Rischmueller22,
  23. S.-K. Kwok23,
  24. G. Nordmark24,
  25. Y. Suzuki25,
  26. R. Giacomelli26,
  27. V. Devauchelle-Pensec27,
  28. M. Bombardieri28,
  29. B. Hofauer29,
  30. H. Bootsma30,
  31. D. Hammenfors31,
  32. G. Fraile32,
  33. S. Carsons33,
  34. T. Gheita34,
  35. J. Morel35,
  36. C. Vollenveider36,
  37. F. Atzeni37,
  38. S. Retamozo38,
  39. I.-F. Horvath3,
  40. K. Sivils4,
  41. E. Theander6,
  42. P. Sandhya10,
  43. S. De Vita11,
  44. J. Sanchez-Guerrero13,
  45. E. van der Heijden14,
  46. V. Moça-Trevisano39,
  47. M. Wahren-Herlenius16,
  48. X. Mariette5,
  49. M. Ramos-Casals1,
  50. on behalf of EULAR SS Task Force
  1. 1Hospital Clinic, Barcelona, Spain
  2. 2Mimar Sinan Univ, Istanbul, Turkey
  3. 3Debrecen Univ, Debrecen, Hungary
  4. 4OMRF, Oklahoma, United States
  5. 5Paris-Sud Univ, Paris, France
  6. 6Lund Univ, Malmö, Sweden
  7. 7Anhui Hosp, Hefei, China
  8. 8Rheumatol Clinic, Pisa, Italy
  9. 9Strasbourg Univ, Strasbourg, France
  10. 10Christian Med Coll, Vellore, India
  11. 11Santa Maria Misericordia Hosp, Udine
  12. 12Sapienza Univ, Roma, Italy
  13. 13INNSZ, Mexico City, Mexico
  14. 14UMCU, Utrecht, Netherlands
  15. 15Espírito Santo Univ, Vitόria, Brazil
  16. 16Karolinska Univ Hosp, Stockholm, Sweden
  17. 17Lariboisière Hosp, Paris, France
  18. 18Perugia Univ, Perugia, Italy
  19. 19Clinical Center Univ, Ljubljana, Slovenia
  20. 20Univ College, London, United Kingdom
  21. 21Vall Hebron Hosp, Barcelona, Spain
  22. 22Queen Elizabeth Hosp, Woodville, Australia
  23. 23Catholic Univ, Seoul, Korea, Republic Of
  24. 24Uppsala Univ, Upssala, Norway
  25. 25Kanazawa Univ, Kanazawa, Japan
  26. 26L'Aquila Univ, L'Aquila, Italy
  27. 27Brest Univ Hosp, Brest, France
  28. 28QMUL, London, United Kingdom
  29. 29Rechts der Isar Hosp, Munich, Germany
  30. 30Groningen Univ, Groningen, Netherlands
  31. 31Haukeland Hosp, Bergen, Norway
  32. 32Ramon Cajal Hosp, Madrid, Spain
  33. 33Stony Brook Univ, Mineola, United States
  34. 34Cairo Univ, Cairo, Egypt
  35. 35Montpellier Hosp, Montpellier, France
  36. 36German Hosp, Buenos Aires, Argentina
  37. 37L. Sacco Univ, Milan, Italy
  38. 38Privado Hosp, Cόrdoba, Argentina
  39. 39Sao Paulo Federal Univ, Sao Paulo, Brazil


Objectives To analyse the diagnostic approach used in the largest international cohort of patients with primary Sjögren syndrome (pSS)

Methods The Big Data Sjögren Project is a multicentre registry formed in 2014 by experts participating in the EULAR-SS Task Force. By January 2016, the database included 8315 consecutive patients fulfilling the 2002 criteria. The main features at diagnosis/recruitment (time of criteria fulfilment) were collected and analysed

Results The cohort included 7753 (93%) women (mean age at diagnosis 53 years). Sicca symptoms were reported in more than 90% of patients at diagnosis (92% for dry eye and 92.5% for dry mouth). The diagnostic tests used included the determination of anti-Ro/La antibodies in 8250 (99%) patients, Schirmer test in 6205 (75%), salivary gland biopsy in 5988 (72%), salivary flows in 4941 (59%), corneal stainings in 3304 (40%), scintigraphy in 2578 (31%) and sialography in 873 (10%) patients. The mean number of diagnostic tests included in the 2002 AE criteria was 4.85 ± 1.44 (of a maximum of 8 different tests), and was higher in patients with negative ANA (5.18 vs 4.80 in ANA+, p<0.001) or negative RF (5.06 vs 4.81 in RF+, p<0.001), and was also higher in American patients vs European or Asian patients (5.28 vs 4.83 and 4.63, respectively). A correlation was found between the number of tests carried out and the number of 2002 criteria finally fulfilled (R=0.48)

Conclusions We found a heterogeneous diagnostic approach of pSS with respect to the number of 2002AE diagnostic tests carried out; the approach varied significantly according to geographic origin and baseline immunological profile

Disclosure of Interest None declared

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