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THU0351 Vitamin D Insufficency Is Associated To Fatigue in Non-Supplemented Women with Systemic Lupus Erythematosus in A Mediterranean Region
  1. T.C. Salman-Monte1,
  2. P. Corzo1,
  3. F. Castro1,
  4. L. Polino1,
  5. V. Torrente-Segarra2,
  6. J. Carbonell-Abello1
  1. 1Rheumatology Department, Hospital del Mar, Barcelona
  2. 2Rheumatology Department, Hospital General Hospitalet-Moisès Broggi, St Joan d'Espi, Spain


Objectives It has been previously reported that vitamin D deficiency is more prevalent among SLE patients than in the general population. We sought to determine the prevalence of vitamin D insufficiency and deficiency and their related factors, its relationship to SLE symptoms and disease activity on a group of supplemented and non-supplemented female SLE patients from the Mediterranean region.

Methods We performed a cross-sectional study including female SLE patients who regularly attended the outpatient Lupus Unit at Parc de Salut Mar-IMAS in Barcelona, from January 2012 and May 2014. Collected data were: sociodemographics; vitamin D supplementation; fatigue degree visual analog scale; pharmacological treatment; main SLE serological markers, Indexes, scales; and plasma levels of 25-hydroxy vitamin D

Results One-hundred and two consecutive female SLE patients were included. Vitamin D overall insufficiency and deficiency were exhibited by 46% and 22.5% of patients, respectively. Vitamin D insufficiency was found in 50% of supplemented and 60% of non-supplemented patients. Among non-supplemented female SLE patients, it was found that patients with Vitamin D insufficiency showed more fatigue (p=0.009) and received more oral corticosteroids (p=0.02) than those with normal levels. Patients with Vitamin D insufficiency (supplemented and non-supplemented) received more oral corticosteroids than those without insufficiency (p=0.008).

Conclusions Vitamin D insufficiency is highly prevalent among female SLE patients, even in southern regions. Non-supplemented female SLE patients showed more fatigue and received more oral corticosteroids than those with normal levels of Vitamin D. This data was not found in supplemented patients despite having a high prevalence of Vitamin D insufficiency (up to 50%). Further studies with longer follow-up and larger population are needed to confirm our observations.

Disclosure of Interest None declared

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