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THU0308 Hydroxychloroquine Improves Pregnancy Outcome in Women with Antiphospholipid Antibodies without Other Underlying Connective Tissue Disease
  1. S. Sciascia1,
  2. S. Baldovino2,
  3. D. Roccatello2,
  4. M.J. Cuadrado3
  1. 1Centro di Ricerche di Immunologia Clinica ed Immunopatologia e Documentazione su Malattie Rare
  2. 2Centro di Ricerche di Immunologia Clinica ed Immunopatologia e Documentazione su Malattie Rare, Torino, Italy
  3. 3Lupus unit, Guy's and St. Thomas' NHS Foundation Trust, London, UK, London, United Kingdom


Background Low-dose aspirin and/or heparins represent the treatment of choice for the management of pregnant women with antiphospholipid antibodies (aPL). However, despite these treatments, maternal, fetal, and neonatal complications related to the presence of aPL may still occur.

Objectives To assess pregnancy outcome in women with aPL without other underlying connective tissue disease (CTD) who were treated with hydroxychloroquine (HCQ) in addition to conventional treatment during pregnancy.

Methods Eighty-nine pregnancies in 48 women with persistent aPL were included in this observational, retrospective, cohort study: (group 1) 17 pregnancies that occurred in 13 women were treated with HCQ for at least 6 months before pregnancy, and the therapy continued throughout gestation; (group 2) 72 pregnancies that occurred in 35 women with aPL that were not treated with HCQ were included as controls. All the patients were tested positive for aPL in the absence of conclusive clinical signs/symptoms of CTD.

Results HCQ-treatment was associated with a higher rate of live births (82% group A vs 58% group B; p=0.05). Placenta-mediated complications (pre-eclampsia and abruption placentae) were not observed in group 1 but occurred in 5 cases of group 2. Pregnancy duration was longer in group 1 than group 2 (36.4 [6–40] vs 33.5 [6–40] weeks; p=0.04).

Conclusions Despite the limit of the small sample size, our observations support that HCQ may improve pregnancy outcome in women with aPL.

Disclosure of Interest None declared

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