Background Acrocyanosis is a disorder of the peripheral circulation and often arises due to cold, and describes the situation with diffuse blue-purplish discoloration of the hands and feet. Although its etiology is unknown, infections, malignancies, hematological disorders, neurological, psychiatric, autoimmune and metabolic status have all been suggested to contribute. It is more frequent in women and usually starts during the third decade. Unless there is another underlying disease, there is no data regarding whether these patients have increased risk of mortality and morbidity or not, compared to a healthy people. Arterial stiffness measurements have long-term high predictive value, accessibility, cost-effectiveness and repeatability for representing cardiovascular risk.
Objectives To investigate long-term cardiovascular risk, determine factors that may play a role in the etiology and measure arterial stiffness in patients with acrocyanosis.
Methods The study included 23 consecutive patients who were diagnosed as acrocyanosis and agreed to participate in the study (F/M: 1/22) and 17 healthy controls (F/M: 1/16) were included. Tensiomed Arteriograph device used for measuring arterial stiffness of the cases. T he demographic and clinical features, blood counts and routine laboratory tests were recorded and their relationships with arterial stiffness measurements were investigated. Correlation and regression analysis were used for the evaluation of the data.
Results The mean age of the patient and control groups were similar (22.83±4.7 and 25.0±0.5 years, respectively, p=0.066). The average body mass indexes of the patient and control groups were also similar (21.6±2.6 and 22.7±1.3 kg/m 2). The average pulse wave velocity measurements were lower in acrocyanosis patients compared to controls, but the difference did not reach statistical significance (6.87 ±1.11 and 7.15±1.37 m/s, p=0.508). Pulse wave velocity measurements were associated with erythrocyte sedimentation rate (r =0.551, p=0.012). Ankle-brachial index (ABI) was associated with serum glucose levels (r =0.896, p<0.001). Serum calcium levels were associated with aortic and brachial augmentation indexes (r =0.477 and 0.474; p=0.045 and 0.047, respectively). Patient and control groups had similar aortic and brachial augmentation indexes, and there was no significant difference between the groups in terms of central aortic pressures.
Conclusions According to our study, arterial stiffness indexes representing cardiovascular risk were similar in patients with acrocyanosis compared to healthy population of the same age. However, the lower average pulse wave velocity measurements in acrocyanosis, need to be further investigated in a larger group.
Disclosure of Interest None declared
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