Background The influence of type 2 diabetes mellitus (T2DM) on development and progression of osteoarthritis (OA) has been proved. However, there is a lack of data from more detailed researches in such category of patients.

Objectives To estimate the proinflammatory serum cytokine levels and the clinical features in patients with knee OA and T2DM depending on glycemic control.

Methods Patients (n=45) who had bilateral knee OA according to ACR criteria and T2DM were divided into two groups according to the compensation degree T2DM taking into account parameters of glycated hemoglobin concentrations (HbA1c) which were assessed using liquid chromatography. Blood glucose level was also estimated. Group 1 (n=26) had control T2DM. Group 2 (n=19) had no control T2DM. All patients were comparable by age, sex and duration of OA. Serum cytokine levels (IL-1b, IL-6, IL-10, IL-18), NO, and adypokines (adiponectin, leptin) using ELISA were assessed. Intensity of pain, general health, stiffness, physical functions were measured by visual analog scale (VAS),Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Knee injury and Osteoarthritis Outcome Score – (KOOS) and short form 36 (SF-36). U-Mann-Whitney test was applied to detect differences between groups. Correlation was assessed using Spearman correlation coefficient (rs).

Results No significant difference has been found in parameters reflecting the functional disorders. Serum cytokines levels also were not different between the studied groups. Correlation analysis identified the relationships between clinical parameters and cytokines in OA patients with control and non-control T2DM. Certain data are presented (Table).

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Conclusions The results show that depending on the glycemic control may change clinical and immunology parameters of OA in patients with T2DM, especially in group with non-control T2DM. These data should be verified by larger studies and may be useful for the development of a personalized approach to patients with comorbid disorders such as OA and T2DM in future.

1. Piva S. R. et al. Links Between Osteoarthritis and Diabetes: Implications for Management from a Physical Activity Perspective //Clinics in geriatric medicine 2015

2. Louati K. et al. Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis //RMD open 2015

3. Esposito K. et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans role of oxidative stress //Circulation 2002

4. Verzijl N. et al. Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis //Arthritis & Rheumatism 2002

Disclosure of Interest None declared