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AB0494 Risk Factors of Heart Disease in Patients with Systemic Lupus Erythematosus
  1. N.A. Ganiyeva,
  2. M.B. Kasymova,
  3. F.K. Ziyayeva,
  4. E.R. Djurayeva,
  5. D.U. Berdiyeva
  1. Internal Disease, Tashkent Medical Academy, Tashkent, Uzbekistan


Background Cardio vascular diseases are caused by premature development of atherosclerotic vascular lesions and thrombotic complications and the third leading cause to death in patients with systemic lupus erythematosus (SLE).

Objectives Identify associated risk factors of cardiovascular disease in patients with SLE.

Methods A total of 92 patients (9 men and 83 women) with a documented diagnosis of SLE according to the ARA criteria. The age of patients ranged from 18 to 55 years of age, disease duration ranged from 3 to 24 years. More than half part of patients with SLE have a subacute course of the disease (78.6%) and the average level of activity (80.2%). In clinical surveys were taken into account family history of cardiovascular disease, smoking, hypertension, diabetes mellitus (DM), body mass index, menopause in women, stress. It was detected biochemical blood tests to determine the lipid profile - total cholesterol, VLDL cholesterol, LDL cholesterol, HDL cholesterol, triglycerides. Also surveyed cerebral circulation according to Doppler ultrasound of the brachiocephalic vessels (SPL cylinder head).

Results Classical cardiovascular risk factors (one or more) occurred in 85 (92.3%) patients. Thus, were the predominant dyslipidemia (78.7% of patients), mainly due to triglyceridemia, increase the level of total cholesterol and low density lipoprotein. Hypertension was detected in 32.7% of patients, smoking - 13.6%, overweight - at 45.4%, family history of cardiovascular disease - at 27.2%, diabetes - at 4.5%, menopause in women - 15.8%, stress - 35% of patients. During the cylinder head ultrasound carotid artery vasoconstriction by type was detected in 77.2% of patients.

Conclusions The results of this study confirm the high probability of the development of atherosclerosis and related complications in SLE patients, which calls for the timely detection and correction of modifiable risk factors.

Disclosure of Interest None declared

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