Gene copy-number variations (CNVs) of complement C4 and C4A deficiency in genetic risk and pathogenesis of juvenile dermatomyositis

Katherine E Lintner; Anjali Patwardhan; Lisa G Rider; Rabheh Abdul-Aziz; Yee Ling Wu; Emeli Lundström; Leonid Padyukov; Bi Zhou; Alaaedin Alhomosh; David Newsom; Peter White; Karla B Jones; Terrance P O'Hanlon; Frederick W Miller; Charles H Spencer; Chack Yung Yu

doi:10.1136/annrheumdis-2015-207762

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Clinical and epidemiological research

Extended report

Gene copy-number variations (CNVs) of complement C4 and C4A deficiency in genetic risk and pathogenesis of juvenile dermatomyositis

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Katherine E Lintner Department of Pediatrics, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA PubMed articles Google scholar articles
Anjali Patwardhan Department of Pediatrics, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA PubMed articles Google scholar articles
Lisa G Rider Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland, USA PubMed articles Google scholar articles
Rabheh Abdul-Aziz Department of Pediatrics, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA PubMed articles Google scholar articles
Yee Ling Wu Department of Pediatrics, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA PubMed articles Google scholar articles
Emeli Lundström Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden PubMed articles Google scholar articles
Leonid Padyukov Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden PubMed articles Google scholar articles
Bi Zhou Department of Pediatrics, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA PubMed articles Google scholar articles
Alaaedin Alhomosh Department of Pediatrics, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA PubMed articles Google scholar articles
David Newsom Department of Pediatrics, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA PubMed articles Google scholar articles
Peter White Department of Pediatrics, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA PubMed articles Google scholar articles
Karla B Jones Department of Pediatrics, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA PubMed articles Google scholar articles
Terrance P O'Hanlon Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland, USA PubMed articles Google scholar articles
Frederick W Miller Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland, USA PubMed articles Google scholar articles
Charles H Spencer Department of Pediatrics, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA PubMed articles Google scholar articles
Chack Yung Yu Department of Pediatrics, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA PubMed articles Google scholar articles

Correspondence to Professor Chack Yung Yu, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA; chack-yung.yu{at}nationwidechildrens.org

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Citation

Lintner KE, Patwardhan A, Rider LG, et al

Gene copy-number variations (CNVs) of complement C4 and C4A deficiency in genetic risk and pathogenesis of juvenile dermatomyositis

Annals of the Rheumatic Diseases 2016;75:1599-1606.

Publication history

Received April 10, 2015
Revised August 8, 2015
Accepted September 20, 2015
First published October 22, 2015.

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November 02, 2019

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