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Correspondence response
Response to: ‘Does the prevalence of radiographic hand osteoarthritis in patients with HIV-1 infection increase or not?’ by Luo et al
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  1. Jérémie Sellam1,2,
  2. Karine Lacombe3,4,
  3. Anne-Laurence Tomi5,
  4. Ida K Haugen6,
  5. David T Felson7,8,9,
  6. Soraya Fellahi2,8,
  7. Jean-Philippe Bastard2,8,
  8. Anne Miquel9,
  9. Manuela Sebire4,
  10. Caroline Rey-Jouvin1,
  11. Emmanuel Maheu1,
  12. Jacqueline Capeau2,8,
  13. Pierre-Marie Girard3,4,
  14. Jean-Luc Meynard3,
  15. Francis Berenbaum1,2
  1. 1Department of Rheumatology, DHU i2B, Saint-Antoine Hospital, Assistance Publique–Hôpitaux de Paris (AP-HP), Paris, France
  2. 2Sorbonnes Universités, UPMC Univ Paris 06, Inserm UMRS_938, DHU i2B, Paris, France
  3. 3Sorbonnes Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d’épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France
  4. 4Department of Infectious Diseases, Saint-Antoine Hospital, AP-HP, Paris, France
  5. 5Department of Rheumatology, Henri Mondor Hospital, AP-HP, Créteil, France
  6. 6Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
  7. 7Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA
  8. 8Department of Biochemistry, Tenon Hospital, AP-HP, Sorbonnes Universités, UPMC Univ Paris 06, Inserm UMR_S938, DHU i2B, IHU ICAN, Paris, France
  9. 9Department of Radiology, Saint-Antoine Hospital, AP-HP, Paris, France
  1. Correspondence to Professor Francis Berenbaum, Saint-Antoine Hospital, Department of Rheumatology, 184 rue du Faubourg Saint-Antoine, Paris 75012, France; francis.berenbaum{at}aphp.fr

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We thank Luo et al1 for their interest in our work demonstrating for the first time that patients with HIV-1 infection display radiographic hand osteoarthritis (HOA) more frequently than the general population and that metabolic syndrome (MetS) is an independent factor associated with HOA presence and severity in the setting of HIV-1 infection.2 We would like to respond point-to-point to each comment.

Not all confounding factors, such as genetic factors, have been taken into account when we compared the prevalence radiographic HOA between the Framingham and the Metabolic Syndrome and Fibrosis-Osteoarthritis (METAFIB-OA) cohorts as well as between patients with HIV-1 infection w/o MetS in the METAFIB-OA cohort. However, a major purpose of our study was to compare the prevalence of HOA in patients who had HIV-1 infection with that from the Framingham cohort. The Framingham Study has been used as a group representative of the general population in many previous studies including in recent lupus studies. …

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