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Extended report
The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis
  1. Zana Brkic1,
  2. Lenny van Bon2,3,
  3. Marta Cossu3,4,
  4. Cornelia G van Helden-Meeuwsen1,
  5. Madelon C Vonk3,
  6. Hanneke Knaapen3,
  7. Wim van den Berg3,
  8. Virgil A Dalm1,
  9. Paul L Van Daele1,
  10. Adriana Severino4,
  11. Naomi I Maria1,
  12. Samara Guillen1,
  13. Willem A Dik1,
  14. Lorenzo Beretta4,
  15. Marjan A Versnel1,
  16. Timothy Radstake2
  1. 1Department of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands
  2. 2Department of Rheumatology, Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
  3. 3Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
  4. 4Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy
  1. Correspondence to Professor Timothy Radstake, Department of Rheumatology & Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3485 CX, The Netherlands; Tradstake73{at}

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