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Reliability of the quantitative assessment of peripheral blood perfusion by laser speckle contrast analysis in a systemic sclerosis cohort

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Footnotes

  • VL, MC and FDK contributed equally

  • Contributors VL, MC, FDK, SD, BR, AS, ED and VS had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study ideation: VS and MC; study design: VS; acquisition of data: VL and VS; database hygiene: SD; analysis and interpretation of data: VL, VS, SD and ED; manuscript preparation and finalisation: VL, MC, FDK, SD, BR, AS, ED and VS.

  • Funding VS is Senior Clinical Investigator of the Research Foundation—Flanders (Belgium) (FWO). VS was supported by an academic grant for the investigator initiated study: ‘To explore and validate use of laser speckle contrast as biomarker and outcome measure in Systemic Sclerosis’ from Actelion Pharmaceuticals Belgium NV.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval This study was approved by the Local Ethical Committee of Ghent University Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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