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Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1β and by the induction of endogenous IL-1Ra

Authors

  • Leo A B Joosten Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands PubMed articlesGoogle scholar articles
  • Tania O Crişan Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands PubMed articlesGoogle scholar articles
  • Tania Azam Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA PubMed articlesGoogle scholar articles
  • Maartje C P Cleophas Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands PubMed articlesGoogle scholar articles
  • Marije I Koenders Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands PubMed articlesGoogle scholar articles
  • Frank L van de Veerdonk Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands PubMed articlesGoogle scholar articles
  • Mihai G Netea Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands PubMed articlesGoogle scholar articles
  • Soohyun Kim Laboratory of Cytokine Immunology, Konkuk University, Seoul, Korea PubMed articlesGoogle scholar articles
  • Charles A Dinarello Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Leo A B Joosten, Department of Internal Medicine (463), Radboud University Medical Center, Geert Grooteplein zuid 8, Nijmegen 6525 GA, The Netherlands; leo.joosten{at}radboudumc.nl
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Citation

Joosten LAB, Crişan TO, Azam T, et al
Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1β and by the induction of endogenous IL-1Ra

Publication history

  • Received November 10, 2014
  • Revised May 22, 2015
  • Accepted June 6, 2015
  • First published July 14, 2015.
Online issue publication 
May 10, 2016

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