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Eicosapentaenoic acid and docosahexaenoic acid are omega-3 polyunsaturated fatty acids with anti-inflammatory effects. They inhibit several pathways like toll-like receptor activation, NALP-3 inflammasome assembly, neutrophil chemotaxis, prostaglandin synthesis and nucleating factor-kB activity through which monosodium urate (MSU) crystals induce inflammation.1–6 In keeping with these findings, mice fed on diet rich in omega-3 fatty acids developed less inflammation after subcutaneous injection of MSU crystals than those on standard diets.1 ,7 Thus, omega-3 fatty acids have the potential of preventing acute attacks of gout. However, the association between omega-3 fatty acid levels and frequency of gout attacks has not been examined in humans. The objective of this study was to examine if omega-3 fatty acid levels associate with frequent gout attacks.
Contributors AA, AMV and MD conceived the study. AA performed the data analysis. AA, AMV and MD critically appraised the manuscript and approved the final version.
Competing interests None declared.
Patient consent Obtained.
Ethics approval Nottinghamshire Research Ethics Committee-1.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement Data used in this study are held in Academic Rheumatology, University of Nottingham, UK, under the custody of MD and can be made available on request.
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