Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis

Yoann Rombouts; Annemiek Willemze; Joyce J B C van Beers; Jing Shi; Priscilla F Kerkman; Linda van Toorn; George M C Janssen; Arnaud Zaldumbide; Rob C Hoeben; Ger J M Pruijn; André M Deelder; Gertjan Wolbink; Theo Rispens; Peter A van Veelen; Tom W J Huizinga; Manfred Wuhrer; Leendert A Trouw; Hans U Scherer; René E M Toes

doi:10.1136/annrheumdis-2014-206598

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Basic and translational research

Extended report

Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis

Authors

Yoann Rombouts Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands PubMed articles Google scholar articles
Annemiek Willemze Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands PubMed articles Google scholar articles
Joyce J B C van Beers Radboud Institute for Molecular Life Sciences and Institute for Molecules and Materials, Radboud University, Nijmegen, the Netherlands PubMed articles Google scholar articles
Jing Shi Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands PubMed articles Google scholar articles
Priscilla F Kerkman Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands PubMed articles Google scholar articles
Linda van Toorn Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands PubMed articles Google scholar articles
George M C Janssen Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands Netherlands Proteomics Centre, Utrecht, the Netherlands PubMed articles Google scholar articles
Arnaud Zaldumbide Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands PubMed articles Google scholar articles
Rob C Hoeben Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands PubMed articles Google scholar articles
Ger J M Pruijn Radboud Institute for Molecular Life Sciences and Institute for Molecules and Materials, Radboud University, Nijmegen, the Netherlands PubMed articles Google scholar articles
André M Deelder Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands PubMed articles Google scholar articles
Gertjan Wolbink Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, the Netherlands Jan van Breemen Research Institute Reade, Amsterdam, the Netherlands PubMed articles Google scholar articles
Theo Rispens Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, the Netherlands PubMed articles Google scholar articles
Peter A van Veelen Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands PubMed articles Google scholar articles
Tom W J Huizinga Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands PubMed articles Google scholar articles
Manfred Wuhrer Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands PubMed articles Google scholar articles
Leendert A Trouw Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands PubMed articles Google scholar articles
Hans U Scherer Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands PubMed articles Google scholar articles
René E M Toes Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands PubMed articles Google scholar articles

Correspondence to Dr Yoann Rombouts, Department of Rheumatology, C-05-61, Leiden University Medical Center, Postbus 9600, Leiden 2300 RC, The Netherlands; y.j.p.c.rombouts{at}lumc.nl

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Citation

Rombouts Y, Willemze A, van Beers JJBC, et al

Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis

Annals of the Rheumatic Diseases 2016;75:578-585.

Publication history

Received September 9, 2014
Revised December 10, 2014
Accepted December 16, 2014
First published January 13, 2015.

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November 02, 2019

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