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Reliability of mSASSS scoring in everyday practice in DESIR-cohort study centres: cross-sectional study of agreement with trained readers
  1. Pascal Claudepierre1,2,
  2. Manouk Sumudu Madushani de Hooge3,
  3. Antoine Feydy4,
  4. Monique Reijnierse5,
  5. Alain Saraux6,7,
  6. Maxime Dougados8,
  7. Désirée van der Heijde3
  1. 1Université Paris Est Créteil, EA 7379-EpiDermE, Creteil, France
  2. 2Department of Rheumatology, AP-HP, Chenevier-Mondor Hospital, Créteil, France
  3. 3Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
  4. 4Radiology B Department, Paris Descartes University, Cochin Hospital, Paris, France
  5. 5Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands
  6. 6Rheumatology Department, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, Brest, France
  7. 7EA 2216, INSERM ESPRI, ERI29 Université Bretagne Occidentale, Brest, France
  8. 8Rheumatology B Department, Paris Descartes University, Cochin Hospital, Paris, France
  1. Correspondence to Professor Pascal Claudepierre, Service de Rhumatologie, Hôpital Henri Mondor, 51 Avenue Maréchal de Lattre de Tassigny, Créteil 94010, France; pascal.claudepierre{at}

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The assessment of axial SpondyloArthritis (axSpA) lesions is important; not only to evaluate a major contributor to disease severity, but also to determine whether drugs are effective in inhibiting structural progression. In trials, assessment of axSpA lesions can be done locally in a study centre, or in a centralised manner by specifically trained readers. The potential impact of choosing one method rather than the other is unknown. In earlier work, we found the same—moderate—level of agreement between local reading (LocR) and central reading (CentR) as between the two central readers regarding radiographic sacroiliitis assessment.1 However, differences between LocR and CentR resulted in misclassification of some patients (ankylosing spondylitis (AS) or axSpA meeting Assessment of SpondyloArthritis international Society (ASAS) criteria).2 The modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) is the recommended tool to assess erosions, sclerosis, squaring and (bridging) syndesmophytes at each anterior vertebral corner of the cervical and lumbar spine.3 ,4 The objective of this study was to assess the agreement between baseline mSASSS values of patients with recent-onset inflammatory back pain (devenir des spondyloarthrites indifférenciées récentes (DESIR) …

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  • PC and MdH contributed equally.

  • Contributors All authors were involved in drafting the article or revising it critically for important intellectual content, and all authors approved the final version to be published. DvdH had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study conception and design: PC, MSMdH and DvdH; acquisition of data: PC, AF, MR, MD, AS and AF; analysis and interpretation of data: MSMdH, PC and DvdH; draft of the manuscript: PC and then MSMdH.

  • Funding Pfizer (Grant for the DESIR cohort).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Paris Ethics Committee for the DESIR cohort.

  • Provenance and peer review Not commissioned; externally peer reviewed.