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Among human macrophages polarised to different phenotypes, the M-CSF-oriented cells present the highest pro-inflammatory response to the rheumatoid arthritis-specific immune complexes containing ACPA
  1. Cyril Clavel1,2,3,4,
  2. Laurie Ceccato1,2,3,
  3. Florence Anquetil1,2,3,
  4. Guy Serre1,2,3,4,
  5. Mireille Sebbag1,2,3
  1. 1INSERM Unité 1056, Toulouse, France
  2. 2CNRS Unité Mixte de Recherche 5165, Toulouse, France
  3. 3Laboratory of Epidermis Differentiation and Rheumatoid Autoimmunity, Université de Toulouse, Université Paul Sabatier, Toulouse, France
  4. 4Laboratory of Cell Biology and Cytology, Centre Hospitalier Universitaire (CHU) de Toulouse, Institut Fédératif de Biologie, Toulouse, France
  1. Correspondence to Dr Cyril Clavel, Unité “Différenciation Épidermique et Auto-immunité Rhumatoïde”; UMR 5165 INSERM-CNRS-Université Paul Sabatier, Hôpital Purpan, Place du Dr Baylac, Toulouse 31059, Cedex 9, France; clavel.c{at}chu-toulouse.fr

Footnotes

  • Handling editor Tore K Kvien

  • GS and MS contributed equally.

  • Contributors CC, MS, FA and GS contributed to conception or design of the study. CC, LC and FA contributed to acquisition of data. CC, LC and MS contributed to their analysis and interpretation. CC and MS wrote the article and revised the final version. GS revised the article. All authors approved the submitted version.

  • Funding This study was supported by grants from the Toulouse III University, the ‘CNRS,’ the ‘INSERM’ and the ‘Société Française de Rhumatologie’.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Author note: Current addresses for FA : La Jolla Institute for Allergy and Immunology, La Jolla, California, USA; MS: Institut de Recherche en Santé Digestive (IRSD), U1220 INSERM-INRA-ENVT-Université Toulouse, France

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Footnotes

  • Handling editor Tore K Kvien

  • GS and MS contributed equally.

  • Contributors CC, MS, FA and GS contributed to conception or design of the study. CC, LC and FA contributed to acquisition of data. CC, LC and MS contributed to their analysis and interpretation. CC and MS wrote the article and revised the final version. GS revised the article. All authors approved the submitted version.

  • Funding This study was supported by grants from the Toulouse III University, the ‘CNRS,’ the ‘INSERM’ and the ‘Société Française de Rhumatologie’.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Author note: Current addresses for FA : La Jolla Institute for Allergy and Immunology, La Jolla, California, USA; MS: Institut de Recherche en Santé Digestive (IRSD), U1220 INSERM-INRA-ENVT-Université Toulouse, France

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