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An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation

Authors

  • Amity R Roberts Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Matteo Vecellio Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Liye Chen Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Anna Ridley Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Adrian Cortes Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Julian C Knight Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Paul Bowness Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Carla J Cohen Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • B Paul Wordsworth Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Professor B Paul Wordsworth, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK; paul.wordsworth{at}ndorms.ox.ac.uk
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Citation

Roberts AR, Vecellio M, Chen L, et al
An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation

Publication history

  • Received September 22, 2015
  • Accepted February 2, 2016
  • First published February 25, 2016.
Online issue publication 
November 10, 2016

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