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  • An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation

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Basic and translational research
Extended report
An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation

Authors

  • Amity R Roberts Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Matteo Vecellio Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Liye Chen Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Anna Ridley Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Adrian Cortes Division of Clinical Neurology, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Julian C Knight Wellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Paul Bowness Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Carla J Cohen Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • B Paul Wordsworth Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Professor B Paul Wordsworth, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK; paul.wordsworth{at}ndorms.ox.ac.uk
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Citation

Roberts AR, Vecellio M, Chen L, et al
An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation
Annals of the Rheumatic Diseases 2016;75:2150-2156.

Publication history

  • Received September 22, 2015
  • Accepted February 2, 2016
  • First published February 25, 2016.
Online issue publication 
October 25, 2017

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/