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  • PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth

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Basic and translational research
Extended report
PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth
  1. Ranjan Kc1,
  2. Xin Li1,
  3. Jeffrey S Kroin2,
  4. Zhiqiang Liu1,
  5. Di Chen1,
  6. Guozhi Xiao1,3,
  7. Brett Levine4,
  8. Jinyuan Li2,
  9. John L Hamilton1,
  10. Andre J van Wijnen5,
  11. Margaret Piel1,
  12. Daniel A Shelly6,
  13. Dovrat Brass7,
  14. Ela Kolb7,
  15. Hee-Jeong Im1,4,8,9,10
  1. 1Department of Biochemistry, Rush University Medical Center, Chicago, Illinois, USA
  2. 2Department of Anesthesiology, Rush University Medical Center, Chicago, Illinois, USA
  3. 3Department of Biology and Shenzhen Key Laboratory of Cell Microenvironment, South University of Science and Technology of China, Shenzhen, China
  4. 4Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, USA
  5. 5Departments of Orthopedic Surgery & Biochemistry & Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA
  6. 6Novozymes Biopharma US, Franklinton, North Carolina, USA
  7. 7Alomone Labs Ltd, Jerusalem, Israel
  8. 8Department of Internal Medicine (Section of Rheumatology), Rush University Medical Center, Chicago, Illinois, USA
  9. 9Department of Bioengineering, University of Illinois at Chicago, Illinois, USA
  10. 10Jesse Brown Veterans Affairs Medical Center at Chicago, Illinois, USA
  1. Correspondence to Dr Hee-Jeong Im, Rush University Medical Center, Cohn Research BD 516, 1735 W. Harrison, Chicago, IL 60612, USA; Hee-Jeong_Sampen{at}rush.edu

Abstract

This article has been retracted.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/annrheumdis-2015-208444

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