Table of contents

Basic and translational research

• Extended report: IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis (10 May, 2016)

  Eric Gracey, Zoya Qaiyum, Ibrahim Almaghlouth, Daeria Lawson, Susan Karki, Naga Avvaru, Zhenbo Zhang, Yuchen Yao, Vidya Ranganathan, Yuriy Baglaenko, Robert D Inman
• Extended report:

  PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth

  (18 January, 2016)

  Ranjan Kc, Xin Li, Jeffrey S Kroin, Zhiqiang Liu, Di Chen, Guozhi Xiao, Brett Levine, Jinyuan Li, John L Hamilton, Andre J van Wijnen, Margaret Piel, Daniel A Shelly, Dovrat Brass, Ela Kolb, Hee-Jeong Im
• Extended report: Treatment with abatacept prevents experimental dermal fibrosis and induces regression of established inflammation-driven fibrosis (24 February, 2016)

  Matthieu Ponsoye, Camelia Frantz, Nadira Ruzehaji, Carole Nicco, Muriel Elhai, Barbara Ruiz, Anne Cauvet, Sonia Pezet, Marie Laure Brandely, Frédéric Batteux, Yannick Allanore, Jérôme Avouac
• Extended report:

  An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation

  (25 February, 2016)

  Amity R Roberts, Matteo Vecellio, Liye Chen, Anna Ridley, Adrian Cortes, Julian C Knight, Paul Bowness, Carla J Cohen, B Paul Wordsworth
• Extended report: Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis (26 February, 2016)

  Cristina Municio, Blanca Soler Palacios, Lizbeth Estrada-Capetillo, Alberto Benguria, Ana Dopazo, Elena García-Lorenzo, Salvador Fernández-Arroyo, Jorge Joven, María Eugenia Miranda-Carús, Isidoro González-Álvaro, Amaya Puig-Kröger
• Extended report: PPARβ/δ directs the therapeutic potential of mesenchymal stem cells in arthritis (8 March, 2016)

  P Luz-Crawford, N Ipseiz, G Espinosa-Carrasco, A Caicedo, G Tejedor, K Toupet, J Loriau, C Scholtysek, C Stoll, M Khoury, D Noël, C Jorgensen, G Krönke, F Djouad
• Extended report: Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis (9 March, 2016)

  Nadira Ruzehaji, Camelia Frantz, Matthieu Ponsoye, Jerome Avouac, Sonia Pezet, Thomas Guilbert, Jean-Michel Luccarini, Pierre Broqua, Jean-Louis Junien, Yannick Allanore
• Extended report: Among human macrophages polarised to different phenotypes, the M-CSF-oriented cells present the highest pro-inflammatory response to the rheumatoid arthritis-specific immune complexes containing ACPA (23 March, 2016)

  Cyril Clavel, Laurie Ceccato, Florence Anquetil, Guy Serre, Mireille Sebbag
• Extended report: Dysregulated bioenergetics: a key regulator of joint inflammation (24 March, 2016)

  M Biniecka, M Canavan, T McGarry, W Gao, J McCormick, S Cregan, L Gallagher, T Smith, J J Phelan, J Ryan, J O'Sullivan, C T Ng, D J Veale, U Fearon
• Extended report: Synovial fluid mononuclear cells provide an environment for long-term survival of antibody-secreting cells and promote the spontaneous production of anti-citrullinated protein antibodies (11 April, 2016)

  Priscilla F Kerkman, Ayla C Kempers, Ellen I H van der Voort, Maikel van Oosterhout, Tom W J Huizinga, René E M Toes, Hans U Scherer
• Concise report: A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Behçet's disease in HLA-B*51 carriers (23 May, 2016)

  Masaki Takeuchi, Michael J Ombrello, Yohei Kirino, Burak Erer, Ilknur Tugal-Tutkun, Emire Seyahi, Yilmaz Özyazgan, Norman R Watts, Ahmet Gül, Daniel L Kastner, Elaine F Remmers