Comparison of adding tocilizumab to methotrexate with switching to tocilizumab in patients with rheumatoid arthritis with inadequate response to methotrexate: 52-week results from a prospective, randomised, controlled study (SURPRISE study)

Yuko Kaneko; Tatsuya Atsumi; Yoshiya Tanaka; Masayuki Inoo; Hitomi Kobayashi-Haraoka; Koichi Amano; Masayuki Miyata; Yohko Murakawa; Hidekata Yasuoka; Shintaro Hirata; Hayato Nagasawa; Eiichi Tanaka; Nobuyuki Miyasaka; Hisashi Yamanaka; Kazuhiko Yamamoto; Tsutomu Takeuchi

doi:10.1136/annrheumdis-2015-208426

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Comparison of adding tocilizumab to methotrexate with switching to tocilizumab in patients with rheumatoid arthritis with inadequate response to methotrexate: 52-week results from a prospective, randomised, controlled study (SURPRISE study)

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Yuko Kaneko Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan PubMed articles Google scholar articles
Tatsuya Atsumi Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan PubMed articles Google scholar articles
Yoshiya Tanaka The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan PubMed articles Google scholar articles
Masayuki Inoo Department of Internal Medicine, Utazu Hospital, Ayauta-gun, Kagawa, Japan PubMed articles Google scholar articles
Hitomi Kobayashi-Haraoka Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan PubMed articles Google scholar articles
Koichi Amano Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan PubMed articles Google scholar articles
Masayuki Miyata Department of Internal Medicine, Fukushima Red-Cross Hospital, Fukushima, Japan PubMed articles Google scholar articles
Yohko Murakawa Department of Rheumatology, Shimane University Faculty of Medicine, Shimane, Japan PubMed articles Google scholar articles
Hidekata Yasuoka Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan PubMed articles Google scholar articles
Shintaro Hirata The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan PubMed articles Google scholar articles
Hayato Nagasawa Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan PubMed articles Google scholar articles
Eiichi Tanaka Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan PubMed articles Google scholar articles
Nobuyuki Miyasaka Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan PubMed articles Google scholar articles
Hisashi Yamanaka Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan PubMed articles Google scholar articles
Kazuhiko Yamamoto Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan PubMed articles Google scholar articles
Tsutomu Takeuchi Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan PubMed articles Google scholar articles

Correspondence to Professor Tsutomu Takeuchi, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; tsutake{at}z5.keio.jp

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Kaneko Y, Atsumi T, Tanaka Y, et al

Annals of the Rheumatic Diseases 2016;75:1917-1923.

Publication history

Received August 14, 2015
Revised October 26, 2015
Accepted November 24, 2015
First published January 5, 2016.

Online issue publication

April 11, 2023

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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