Increased pretreatment serum IFN-β/α ratio predicts non-response to tumour necrosis factor α inhibition in rheumatoid arthritis

Theresa Wampler Muskardin; Priyanka Vashisht; Jessica M Dorschner; Mark A Jensen; Beverly S Chrabot; Marlena Kern; Jeffrey R Curtis; Maria I Danila; Stacey S Cofield; Nancy Shadick; Peter A Nigrovic; E William St Clair; Clifton O Bingham; Richard Furie; William Robinson; Mark Genovese; Christopher C Striebich; James R O'Dell; Geoffrey M Thiele; Larry W Moreland; Marc Levesque; S Louis Bridges; Peter K Gregersen; Timothy B Niewold

doi:10.1136/annrheumdis-2015-208001

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Clinical and epidemiological research

Extended report

Increased pretreatment serum IFN-β/α ratio predicts non-response to tumour necrosis factor α inhibition in rheumatoid arthritis

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Theresa Wampler Muskardin Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Priyanka Vashisht Division of Rheumatology, University of Nebraska Medical Center, Omaha, USA PubMed articles Google scholar articles
Jessica M Dorschner Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Mark A Jensen Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Beverly S Chrabot Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, Illinois, USA PubMed articles Google scholar articles
Marlena Kern Center for Genomics and Human Genetics, Feinstein Institute Medical Research, North Shore LIJ Health System, New York, New York, USA PubMed articles Google scholar articles
Jeffrey R Curtis Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, Alabama, USA PubMed articles Google scholar articles
Maria I Danila Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, Alabama, USA PubMed articles Google scholar articles
Stacey S Cofield Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, Alabama, USA PubMed articles Google scholar articles
Nancy Shadick Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
Peter A Nigrovic Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
E William St Clair Division of Rheumatology and Immunology, Duke University, Durham, USA PubMed articles Google scholar articles
Clifton O Bingham Divisions of Rheumatology and Allergy, Johns Hopkins University, Baltimore, USA PubMed articles Google scholar articles
Richard Furie Division of Rheumatology and Allergy-Clinical Immunology, North Shore-LIJ Health System, Lake success, New York, USA PubMed articles Google scholar articles
William Robinson Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA PubMed articles Google scholar articles
Mark Genovese Division of Immunology and Rheumatology, Stanford University, Stanford, California, USA PubMed articles Google scholar articles
Christopher C Striebich Division of Rheumatology, University of Colorado Denver, Denver, USA PubMed articles Google scholar articles
James R O'Dell Division of Rheumatology, University of Nebraska Medical Center, Omaha, USA PubMed articles Google scholar articles
Geoffrey M Thiele Division of Rheumatology, University of Nebraska Medical Center, Omaha, USA PubMed articles Google scholar articles
Larry W Moreland Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA PubMed articles Google scholar articles
Marc Levesque Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA PubMed articles Google scholar articles
S Louis Bridges Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, Alabama, USA PubMed articles Google scholar articles
Peter K Gregersen Center for Genomics and Human Genetics, Feinstein Institute Medical Research, North Shore LIJ Health System, New York, New York, USA PubMed articles Google scholar articles
Timothy B Niewold Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles

Correspondence to Professor Timothy B Niewold, Division of Rheumatology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA; niewold.timothy{at}mayo.edu

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Citation

Wampler Muskardin T, Vashisht P, Dorschner JM, et al

Increased pretreatment serum IFN-β/α ratio predicts non-response to tumour necrosis factor α inhibition in rheumatoid arthritis

Annals of the Rheumatic Diseases 2016;75:1757-1762.

Publication history

Received May 28, 2015
Revised September 17, 2015
Accepted October 18, 2015
First published November 6, 2015.

Online issue publication

September 09, 2016

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