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Low-dose versus high-dose fish oil for pain reduction and function improvement in patients with knee osteoarthritis
  1. Yan Chen1,2,
  2. Yong-Can Huang1,3,
  3. William W Lu1,4
  1. 1Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, P.R. China
  2. 2Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, P.R. China
  3. 3Orthopedics Research Center, Peking University Shenzhen Hospital, Shenzhen, P.R. China
  4. 4Center for Human Tissue and Organs Degeneration, Shenzhen Institutes of Advanced Technology, CAS, China
  1. Correspondence to Professor William W Lu, Ng Chun-Man Professorship in Orthopaedic Bioengineering, The University of Hong Kong, Room 907, Lab Block, 21 Sassoon Road, Hong Kong 999077, Hong Kong; wwlu{at}

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Osteoarthritis (OA) is one of the leading generators of musculoskeletal pain and the main cause of disability.1 It has been considered an inflammatory disease with low grade inflammation affecting the synovium, cartilage and subchondral bone.2 To date, there is no disease-modifying OA drug.3 A few studies have evaluated the efficacy of fish oil in the treatment of OA;4 nevertheless, the effectiveness and precise benefits of fish oil intake in patients with OA are still far from well understood. We read with deep interest a recent article published in this journal by Hill et al, who found significant improvement of OA pain and function after treatment by fish oil, and suggested that the low-dose fish oil group had much better improvement in pain and function at 2 years in comparison to the high-dose one.5 The authors are congratulated for the excellent findings and we really appreciate the work performed by them; nevertheless, some worthwhile issues need …

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