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Infrapatellar fat pad maximal area and changes in knee symptoms: gender-related difference or gender difference in reporting?
  1. Harrison X Bai1,
  2. Ashley M Lee1,
  3. Zhili Wang2,
  4. Haiyun Tang3,
  5. Li Yang2
  1. 1Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
  2. 2Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
  3. 3Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China
  1. Correspondence to Li Yang, Department of Neurology, The Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Changsha, Hunan 410011, China; yangli762{at}

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We read with interest a recent paper by Pan et al on the relationship between the infrapatellar fat pad (IPFP) and knee osteoarthritis (OA).1 With an average follow-up of 2.6 years, the authors found that IPFP maximal area at baseline was negatively associated with changes in knee pain, but positively associated with change in tibial cartilage volume per annum, and reduced risks of increases in medial cartilage defects. Based on these results, the authors concluded that a higher IPFP maximal area appears to have a protective role for knee symptoms and cartilage damage in older female adults.

We commend the authors for performing the first longitudinal study on the associations between IPFP size at baseline and changes in knee OA measures in community-based older adults. However, we would like to raise several …

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