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MMP2 related disease (Multicentric osteolysis, nodulosis and arthropathy—MONA syndrome—OMIM #259600) consists of a continuous clinical spectrum in terms of severity.1 Even in the same affected individual, different features may present with varying severity (eg, nodulosis may be absent even with severe osteolysis). Till date less than 15 families with MMP2 mutations have been reported2 ,3 and, therefore, it is likely …
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