Objectives The objective of this study is to analyze epidemiologic, clinical, biological, radiological characteristics in the RA.
Methods A total of 300 patients were included with the diagnosis of rheumatoid arthritis meeting ACR 1987 criteria, in a retrospective study, between 2007 and 2012.
Results The average age was 53 years [17- 94]. The predominance was for woman with a sex ratio 8/10. The mean number of years from the onset of RA symptoms until diagnosis was 5 years. The average disease duration was 9 years. The mean value of the DAS 28 was 6.04 [1.2 to 8.5], 96% of patients had an active RA (DAS 28 >3.2). Extra-articular manifestations were reported in 54.25% of patients: secondary Sjögrens syndrome in 22.3%, osteoporosis in 32.6%, rheumatoid nodule in 4.6%, pulmonary fibrosis in 8.4%, cardiac manifestations in 2.3%, medullar compression in 1.3% and carpal tunnel syndrome in 0.6% of cases.
Rheumatoid factor was reported in 68.8% of cases and the mean value of IGA, IGG, IGM was respectively 219, 190 and 246 UI/ml. Anti-citrullinated peptide Antibodies and anti nuclear antibody was reported in 69.6% and 15% of the cases, there mean value were respectively 114 RU/ml and 1/464. Radiological destruction was observed in 91.6% of cases. The mean value of Sharp score was 43.27 [0-180]. There was a positive correlation between DAS 28 and RF (p=0.028) but no significant relation was observed with ACPA and ANA.
Conclusions Rheumatoid arthritis in our study is characterized by its severity, higher disease activity and a later diagnosis; this is why we need a better management of RA, to alter the course of this progressive disease.
Disclosure of Interest None declared
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