Background Autoantibodies against C1q (anti-C1q) have been described a lot in adult patients with systemic lupus erythromatosus (SLE), where they were strongly significant with the occurrence of severe lupus nephritis (LN). However, due to the few clinical studies held in the field of pediatric rheumatology its role has not been well determined in children with systemic lupus erythromatosus.
Objectives To evaluate serum anti-C1q antibodies in pediatric systemic lupus erythromatosus (pSLE) to determine its clinical and statistical association in nephritis activity in comparison to anti-dsDNA
Methods Sera from 44 pSLE patients and 30 healthy individuals were collected. Anti-C1q, Anti-dsDNA, ANA, were measured by enzyme-linked immunosorbant assays. Patient records were evaluated for clinical and laboratory associations
Results Anti-C1q antibodies were more prevalent than anti-ds DNA (n=41,93.2%)in pSLE patients of the current study, which correlated significantly with proteinuria and decreased complement levels (p<0.05). Anti-C1q levels were significantly elevated in patients with class III/IV nephritis compared II/V nephritis. pSLE patients with active nephritis at the time of sample collection demonstrated significantly elevated levels of anti-C1q antibodies compared to those without active nephritis. Anti-C1q antibodies were more sensitive and specific than anti-dsDNA in pSLE patients
Conclusions This study indicates the importance of measuring anti-C1q antibodies in pSLE patients because elevated anti-C1q antibodies may be more indicative and specific for detecting disease activity, showing significant correlation with proteinuria and active nephritis than anti-DNA antibodies
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Acknowledgements I would like to thank all my supervisors for thier expert advice and encouragement through out this study
Disclosure of Interest None declared
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