Background The protective role of saliva in the case of esophageal exposition to gastric acid has long been studied but some contradictions still remain.
Objectives The main end-point of this study was to evaluate if a qualitative and quantitative alteration in salivary secretion exists in sjögren syndrome patients affected by gastro-esophageal reflux disease (GERD).
Methods 20 sjögren syndrome patients with endoscopically diagnosed GERD (LA classification A-D) and 10 sjögren syndrome patients without GERD have been evaluated; salivary tests (basal flow rate, stimulated flow rate, pH, [Na+] and [K+]) were performed, socio-demographical variables and oral GERD-related symptoms were taken into account.
Results Sjögren syndrome patients with GERD and sjögren syndrome patients without GERD were found to have a similar basal flow rate but different stimulated salivary function [sjögren syndrome with GERD group mean value 0.989 ml/min (±0.48718) vs. sjögren syndrome without GERD group 1.2197 ml/min (±0.6108), pH [sjögren syndrome group mean value 8.935 (±0.471) vs. sjögren syndrome without GERD group 7.879 (±0.526)] and a higher K+ concentration. In sjögren syndrome with GERD patients we also registered a significant association with severe xerostomia [18/20 vs. 3/10] and severe an oral burning sensation [17/20 vs. 2/10].
Conclusions Our findings assess that variation of saliva is altered in sjögren syndrome with GERD patients and highlight the need for further investigations in order to define the role of saliva in the etiology of GERD in sjögren syndrome.
Early events in Sjögren's Syndrome pathogenesis: The importance of innate immunity in disease initiation. Cytokine 67 (2014) 92–101.
Disclosure of Interest None declared
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