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Correspondence response
Response to: ‘Is chondroitin sulfate plus glucosamine superior to placebo in the treatment of knee osteoarthritis?’ by Zeng et al
  1. Marc C Hochberg
  2. on behalf of the MOVES Investigation Group
  1. University of Maryland School of Medicine, Baltimore, Maryland, USA
  1. Correspondence to Professor Marc C Hochberg, University of Maryland School of Medicine, 10 S. Pine St., MSTF 8-34, Baltimore, MD 21201, USA; mhochber{at}

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We would like to thank Zeng et al1 for their comments on the Multicentre Osteoarthritis interVEntion trial with SYSADOA (MOVES)2 and the Glucosamine/chondroitin Arthritis Intervention Trial (GAIT)3 and its long-term follow-up.4

In MOVES,2 glucosamine plus chondroitin sulfate was non-inferior to celecoxib (primary outcome: mean decrease in Western Ontario and McMaster (WOMAC) pain score) in 606 patients with knee osteoarthritis with moderate–severe pain. A placebo arm was not included because celecoxib, the reference treatment, had proven efficacy versus placebo in knee osteoarthritis, for example5 ,6; so, this was felt to be unethical and unnecessary. While Zeng et al1 agreed with this decision, they brought up some interesting points.

The original 24-week …

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