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As we noted in our paper reporting results of the BRACE trial,1 a trial of patellar bracing in patellofemoral osteoarthritis (OA), we did not use a placebo control because all such feasible controls recapitulated at least one mechanism of action of the patellar brace, and we were interested in examining whether any action of the brace might be therapeutic. Our means of demonstrating the effect of the brace was to examine compartment-specific bone marrow lesion (BML) change on MRI in addition …
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