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Correspondence response
Response to: ‘The effects of a brace for patellofemoral osteoarthritis targeting knee pain and bone marrow lesions were overestimated or not?’ by Zeng et al
  1. Michael Callaghan1,
  2. Matthew Parkes1,
  3. David T Felson1,2
  1. 1University of Manchester, Manchester, UK
  2. 2Boston University School of Medicine, Boston, Massachusetts, USA
  1. Correspondence to Professor David T Felson, Boston University School of Medicine, A203, 80 E. Concord Street, Boston, MA 2118, USA; dfelson{at}

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As we noted in our paper reporting results of the BRACE trial,1 a trial of patellar bracing in patellofemoral osteoarthritis (OA), we did not use a placebo control because all such feasible controls recapitulated at least one mechanism of action of the patellar brace, and we were interested in examining whether any action of the brace might be therapeutic. Our means of demonstrating the effect of the brace was to examine compartment-specific bone marrow lesion (BML) change on MRI in addition …

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