Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

Yue Zhang; Faezeh Vasheghani; Ying-hua Li; Meryem Blati; Kayla Simeone; Hassan Fahmi; Bertrand Lussier; Peter Roughley; David Lagares; Jean-Pierre Pelletier; Johanne Martel-Pelletier; Mohit Kapoor

doi:10.1136/annrheumdis-2013-204599

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Basic and translational research

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Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

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Yue Zhang Osteoarthritis Research Unit, University of Montreal Research Centre (CRCHUM), Montreal, Quebec, Canada PubMed articles Google scholar articles
Faezeh Vasheghani Osteoarthritis Research Unit, University of Montreal Research Centre (CRCHUM), Montreal, Quebec, Canada PubMed articles Google scholar articles
Ying-hua Li Osteoarthritis Research Unit, University of Montreal Research Centre (CRCHUM), Montreal, Quebec, Canada PubMed articles Google scholar articles
Meryem Blati Osteoarthritis Research Unit, University of Montreal Research Centre (CRCHUM), Montreal, Quebec, Canada PubMed articles Google scholar articles
Kayla Simeone Osteoarthritis Research Unit, University of Montreal Research Centre (CRCHUM), Montreal, Quebec, Canada PubMed articles Google scholar articles
Hassan Fahmi Osteoarthritis Research Unit, University of Montreal Research Centre (CRCHUM), Montreal, Quebec, Canada PubMed articles Google scholar articles
Bertrand Lussier Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, Montreal, Quebec, Canada PubMed articles Google scholar articles
Peter Roughley Genetics Unit, Shriners Hospital, McGill University, Montreal, Quebec, Canada PubMed articles Google scholar articles
David Lagares Pulmonary and Critical Care Unit and Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Massachusetts, USA PubMed articles Google scholar articles
Jean-Pierre Pelletier Osteoarthritis Research Unit, University of Montreal Research Centre (CRCHUM), Montreal, Quebec, Canada PubMed articles Google scholar articles
Johanne Martel-Pelletier Osteoarthritis Research Unit, University of Montreal Research Centre (CRCHUM), Montreal, Quebec, Canada PubMed articles Google scholar articles
Mohit Kapoor Osteoarthritis Research Unit, University of Montreal Research Centre (CRCHUM), Montreal, Quebec, Canada Division of Genetics and Development, The Toronto Western Research Institute, Toronto Western Hospital, The University Health Network (UHN), Toronto, Ontario, Canada PubMed articles Google scholar articles

Correspondence to Dr Mohit Kapoor, Division of Genetics and Development, The Toronto Western Research Institute, Toronto Western Hospital, The University Health Network (UHN), 60 Leonard Avenue, Toronto, Ontario, Canada M5T 2S8; mkapoor{at}uhnresearch.ca

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Citation

Zhang Y, Vasheghani F, Li Y, et al

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

Annals of the Rheumatic Diseases 2015;74:1432-1440.

Publication history

Received September 11, 2013
Revised February 11, 2014
Accepted February 16, 2014
First published March 20, 2014.

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November 02, 2019

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