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We thank Dr Meyer1 for his comments on the Glucosamine/chondroitin Arthritis Intervention Trial (GAIT)2 and the Multicentre Osteoarthritis interVEntion trial with SYSADOA (MOVES).3
In GAIT, carried out during 2000–2004, 1583 patients with symptomatic knee osteoarthritis (OA) were randomised to glucosamine, chondroitin sulfate, glucosamine plus chondroitin sulfate, celecoxib or placebo. As Dr Meyer pointed out, there was a strong placebo response; after 24 weeks, 60.1% of the placebo group had a 20% decrease in Western Ontario and McMaster Osteoarthritis Index (WOMAC) pain score (primary outcome). However, Dr Meyer said that ‘GAIT failed to show a difference for any treatment in the change from baseline’; the response rates in the four treatment groups were 64.0% for …