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Circulating C reactive protein in osteoarthritis: a systematic review and meta-analysis
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  • Published on:
    Re: Paying attention to arbitrary causality and the preciseness of conclusion

    Dear Editor,

    We would like to thank Dr. Lei for the comments on our paper. Please see the point-to-point response as below:

    1. As pointed out in the discussion of our paper, cross-sectional and case-control designs are not able to infer a causal relationship. The conclusion 'low grade systemic inflammation may play a greater role in symptoms rather than radiographic changes in OA' does not necessarily...

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    Conflict of Interest:
    None declared.
  • Published on:
    Paying attention to arbitrary causality and the preciseness of conclusion
    • Guang-hua Lei, Doctor
    • Other Contributors:
      • Chao Zeng, Shu-guang Gao, Guang-hua Lei

    Dear Editor,

    We read with deep interest the article by Jin et al1 related to relationship between serum C reactive protein (CRP) levels measured by a high sensitivity method and osteoarthritis (OA), as well as the correlation between circulating CRP levels and OA phenotypes. We really appreciate the work which was done by the authors. However, after reading there are some worthwhile issues needs to explore....

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    Conflict of Interest:
    None declared.