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Response to: ‘Is primary Sjögren's syndrome an orphan disease? A critical appraisal of prevalence studies in Europe’ by Cornec and Chiche
  1. Baodong Qin1,
  2. Jiaqi Wang2,
  3. Zaixing Yang1,
  4. Yan Liang1,
  5. Renqiang Zhong1
  1. 1Department of Laboratory Diagnostics, Chang Zheng Hospital, Second Military Medical University, Shanghai, China
  2. 2Department of Stomatology, Changzheng Hospital, Second Military Medical University, Shanghai, China
  1. Correspondence to Baodong Qin, Department of Laboratory Diagnostics, Chang zheng Hospital, Second Military Medical University, Shanghai 200003, China; qbdchn11{at}

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We thank Divi Cornec and Laurent Chiche1 for their valuable comments on our article.2 We think that the majority of remarks they made were reasonable and helpful for a deep understanding of the prevalence of primary Sjögren's syndrome (pSS). Due to the great differences between a population-based study and sample survey, it is obvious that a high heterogeneity (p<0.001 for Q statistic, I2=98.95%) could be observed across these articles when conducting a meta-analysis. According to the definition of a rare disease, the total prevalence rate from our study did show that pSS is not a rare disease (one case in 1644). But the prevalence rate was one case per 2304 persons when only considering a population-based study, suggesting pSS is a rare disease.

Among the included studies in our paper, pSS …

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