Article Text

FRI0431 Venous and Arterial Thrombosis in Sle: Differences in Natural History
  1. K. Hickman1,
  2. L. Magder2,
  3. M. Petri3
  1. 1University College London Medical School, London, United Kingdom
  2. 2Epidemiology & Public Health, University of Maryland School of Medicine
  3. 3Division of Rheumatology, Johns Hopkins University, Baltimore, United States


Background Thrombosis is increased in SLE due to disease activity and co-morbid factors including antiphospholipid antibodies. We separately investigated the natural history of venous vs. arterial thrombosis.

Methods 2250 patients were enrolled in a prospective cohort; 334 had a thrombotic event before cohort entry or diagnosis of SLE. For ALL thrombosis, age over 60 yrs, male gender, African-American ethnicity, SLEDAI greater than 3, and prednisone greater than 0 were risk factors. In general, rates of venous thrombosis were fairly constant, while rates of arterial thrombosis increased with age.

Results See Table 1.

Table 1.

Incidence rates (per 1000 patient-years) of thrombosis

Conclusions Prevention of venous thrombosis remains important throughout the course of SLE. Prevention of arterial thrombosis becomes more important later in the disease course. Disease activity is more of a risk factor for arterial thrombosis while prednisone is a risk factor for both venous and arterial thrombosis.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.3776

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