Objectives To investigate the associations of rheumatoid factor (RF) and autoantibodies against citrullinated proteins (ACPA) with rheumatoid arthritis (RA) disease activity.
Methods We used baseline data from four recent randomized controlled clinical trials of RA (one in early RA patients on rituximab, RTX; three on golimumab, GOL, in early and established populations). The effects of RF and ACPA on individual and composite measures of disease activity were investigated by using stratified analysis and a matched analysis.
Results A total of 2118 patients were analysed in the four studies. In both, the RTX and the pooled GOL cohorts, RF+ patients, regardless of ACPA status, had the highest levels of baseline disease activity, while ACPA+ patients had similar or lower disease activity than ACPA- patients, regardless of RF status (See Figure, using Simplified Disease Acitivty Index, SDAI).
When patients from the RTX trial were matched for the levels of ACPA, as well as for age, gender, and duration of RA (n=29), SDAI levels were 49.3±14.5 in the presence of high positive RF, and 42.3±12.7 in patients who were RF negative; this was the opposite for ACPA in patients matched for RF levels and the same covariates: high positive ACPA: 45.8±14.8; ACPA negative: 53.1±16.5 (p=0.025). These trends were supported in the respective analyses in the pooled GOL trials (RF high vs. neg.: SDAI of 36.8 vs. 33.1; ACPA high vs. neg.: 37.0 vs. 39.5), although the difference did not reach statistical significance.
Figure. Simplified Disease Activity Index at baseline of the rituximab trial (left panel) or the pooled golimumab trials (right panel) by groups of RF/ACPA status.
Conclusions The data suggest that the presence of RF rather than ACPA is related to higher disease activity. When matched for RF levels, ACPA had little influence on disease activity, if at all, with the tendency towards lower disease activity for ACPA+ patients.
Acknowledgements We thank Roche and Janssen for providing anonymised patient level data from their clinical trials.
Disclosure of Interest : None declared
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