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THU0056 Acute Aerobic Exercise Induces Increases on Plasma Levels of α-Melanocyte Stimulating Hormone in Patients with Active Systemic Lupus Erythematosus
  1. L. Perandini1,
  2. B. Gualano2,
  3. A.L.D.S. Pinto1,
  4. F. Lima1,
  5. E. Bonfá1,
  6. E.F. Borba1,
  7. H. Roschel2,
  8. S.B. Mello1
  1. 1Internal Medicine, Rheumatology Division, School of Medicine, University of São Paulo
  2. 2School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil


Background Systemic lupus erythematosus (SLE) is an autoimmune disease associated with chronic inflammation. Pro-opiomelanocortin (POMC) axis activation leads to the production of several bioactive hormones, such as adrenocorticotropic hormone (ACTH) and the neuropeptide α-melanocyte stimulating hormone (α-MSH). Both hormones are closely related to the inflammatory process with pro- or anti-inflammatory effects. Although physical exercise has been described as a promoter of alterations in the neuroendocrine profile, no studies have addressed the participation of melanocortins in SLE patients in response to acute aerobic exercise.

Objectives To evaluate α-MSH production in SLE patients under acute aerobic exercise.

Methods Ten active SLE patients [age: 29.9±4.2yrs; body mass index (BMI): 26.0±4.8 kg/m2; SLEDAI: 5.9±2.1; glucocorticoid: 16.0±6.0 mg] and 10 age- and BMI-matched healthy controls performed 30 minutes of aerobic exercise (∼70% of VO2 peak) in a treadmill. The a-MSH and ACTH serum levels were assessed at baseline and immediately after exercise session by a multiplex system (HNP-35K kit, Millipore, Billerica, MA, USA).

Results Similar levels of a-MSH were observed at baseline between active SLE patients and healthy controls (P=0.69). However, after exercise, a distinct pattern of response was noted (Fig. 1). The serum levels of a-MSH was not altered in healthy controls, but a significant increase in mean levels was observed in active SLE patients after exercise (92.39±16.12 vs. 146.23±25.01 pg/mL, P=0.04). ACTH levels did not differ between groups at baseline and after exercise (P>0.05).

Figure 1.

α-MSH response to acute session of aerobic exercise in active SLE patients ad healthy controls.

Conclusions The present study provides novel evidence that acute aerobic exercise induces a hypothalamic-pituitary-adrenal axis response with an increase in the levels of neuropeptide α-MSH in active SLE patients. We speculate that this is an exacerbated adaptive response to exercise stress to avoid further stimulation of proinflammatory cytokines in these patients.

Disclosure of Interest : None declared

DOI 10.1136/annrheumdis-2014-eular.5206

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