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Drs Fleishman and Yazici pose several worthwhile questions.1 It is important to appreciate that this was not a clinical trial, but rather a classic pharmacokinetic study. Unlike previous studies, ours compared commonly used doses of two different formulations of methotrexate (MTX), subcutaneous (SC) and oral. The key concept demonstrated is that the absorption of oral MTX is both variable and saturable. Because there is extensive overlap in the …
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