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Correspondence response
Response to: ‘Is there a direct relationship between serum level of methotrexate and clinical efficacy and tolerability?’ by Fleishman and Yazici
  1. Michael H Schiff1,
  2. Jonathan S Jaffe2,
  3. Bruce Freundlich3
  1. 1Department of Rheumatology, University of Colorado, Englewood, Colorado, USA
  2. 2Clinical Development, Antares Pharma Inc, Ewing, New Jersey, USA
  3. 3Medical Department, Antares Pharma Inc, Ewing, New Jersey, USA
  1. Correspondence to Dr Michael H Schiff, Department of Rheumatology, University of Colorado, 5400 South Monaco, Englewood, Colorado CO 80111, USA; michael.schiff{at}

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Drs Fleishman and Yazici pose several worthwhile questions.1 It is important to appreciate that this was not a clinical trial, but rather a classic pharmacokinetic study. Unlike previous studies, ours compared commonly used doses of two different formulations of methotrexate (MTX), subcutaneous (SC) and oral. The key concept demonstrated is that the absorption of oral MTX is both variable and saturable. Because there is extensive overlap in the …

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  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.

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