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We would like to thank Brink et al1 for their interest in our paper. The authors reported that antibodies against arginine-containing peptides from rheumatoid arthritis (RA) autoantigens were present in a population-based sample of 386 individuals with pre-RA. These pre-dated the corresponding antibodies against citrullinated peptides which appeared closer to onset of symptoms.
These results are in line with our results, …
Contributors All authors were involved in drafting the article or revising it critically for important intellectual content, and all authors approved the final version.
Funding This work was supported by ‘Gums & Joints’, a European Union FP7 Grant FP7 HEALTH-F2-2010-261460 and ‘RAPID’, a European Union funded ITN project 290246.
Competing interests None.
Provenance and peer review Commissioned; internally peer reviewed.
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