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We have read the article by de Pablo et al1 with great interest. The authors reported higher frequencies of antibodies against the uncitrullinated form of fibrinogen and of the arginine containing α-enolase peptide-1 in patients with periodontitis compared with patients without periodontitis. As a consequence of their study the authors concluded that antibodies to uncitrullinated versions of rheumatoid arthritis (RA) associated autoantigens may occur before the development of anticitrullinated peptide/protein antibodies. This encouraged us to analyse the data for individuals identified in the Medical Biobank of Northern Sweden as having donated blood samples before the onset of the symptoms of RA with regard to the first time point when different autoantibody specificities were detectable.
Contributors All authors were involved in drafting the article or revising it critically for important intellectual content, and all authors approved the final version to be published. SRD had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study conception and design: MB, SRD. Acquisition of data: MB, MH, SRD. Analysis and interpretation of data, drafting the article or revising it critically for important intellectual content, final approval of the version published: MB, MH, JR, LK, SRD.
Competing interests None.
Patient consent Obtained.
Provenance and peer review Not commissioned; internally peer reviewed.
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