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Associations of CTX-II with biochemical markers of bone turnover raise questions about its tissue origin: new insights from CHECK

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  • Contributors BdK wrote the letter, together with WEvS, using data from the CHECK study with approval of FPJGL. FPJGL helped directing the letter in the end.

  • Funding FPJGL reports grants from Dutch Arthritis Association, during the conduct of the study

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Local ethical committees of all participating medical centres.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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