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The urinary level of the carboxy-terminal telopeptide of collagen type II (uCTX-II) currently is one of the most frequently used biochemical markers for assessing collagenolysis in articular cartilage during osteoarthritis. However, we published data suggesting release of CTX-II epitope from bone in Cohort Hip and Cohort Knee (CHECK), a large cohort of subjects with very early stage knee and/or hip osteoarthritis. As was observed for markers of bone metabolism, uCTX-II showed an abrupt increase in women aged 48–53 years that appeared to be attributable to menopause.1 Moreover, earlier work had already shown that uCTX-II has specifically strong associations with marker of bone metabolism as compared …
Footnotes
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Contributors BdK wrote the letter, together with WEvS, using data from the CHECK study with approval of FPJGL. FPJGL helped directing the letter in the end.
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Funding FPJGL reports grants from Dutch Arthritis Association, during the conduct of the study
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Competing interests None.
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Patient consent Obtained.
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Ethics approval Local ethical committees of all participating medical centres.
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Provenance and peer review Not commissioned; internally peer reviewed.
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