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The urinary level of the carboxy-terminal telopeptide of collagen type II (uCTX-II) currently is one of the most frequently used biochemical markers for assessing collagenolysis in articular cartilage during osteoarthritis. However, we published data suggesting release of CTX-II epitope from bone in Cohort Hip and Cohort Knee (CHECK), a large cohort of subjects with very early stage knee and/or hip osteoarthritis. As was observed for markers of bone metabolism, uCTX-II showed an abrupt increase in women aged 48–53 years that appeared to be attributable to menopause.1 Moreover, earlier work had already shown that uCTX-II has specifically strong associations with marker of bone metabolism as compared …
Contributors BdK wrote the letter, together with WEvS, using data from the CHECK study with approval of FPJGL. FPJGL helped directing the letter in the end.
Funding FPJGL reports grants from Dutch Arthritis Association, during the conduct of the study
Competing interests None.
Patient consent Obtained.
Ethics approval Local ethical committees of all participating medical centres.
Provenance and peer review Not commissioned; internally peer reviewed.
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