You are here

  • Home
  • Archive
  • Volume 73, Issue 7
  • Associations of CTX-II with biochemical markers of bone turnover raise questions about its tissue origin: new insights from CHECK

Article Text

Article menu
Download PDFPDF
Electronic pages
Letter
Associations of CTX-II with biochemical markers of bone turnover raise questions about its tissue origin: new insights from CHECK
  1. B de Klerk,
  2. F P J G Lafeber,
  3. W E van Spil
  1. Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
  1. Correspondence to B de Klerk, Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; bo.deklerk{at}gmail.com
View Full Text

http://dx.doi.org/10.1136/annrheumdis-2014-205494

Statistics from Altmetric.com

    The urinary level of the carboxy-terminal telopeptide of collagen type II (uCTX-II) currently is one of the most frequently used biochemical markers for assessing collagenolysis in articular cartilage during osteoarthritis. However, we published data suggesting release of CTX-II epitope from bone in Cohort Hip and Cohort Knee (CHECK), a large cohort of subjects with very early stage knee and/or hip osteoarthritis. As was observed for markers of bone metabolism, uCTX-II showed an abrupt increase in women aged 48–53 years that appeared to be attributable to menopause.1 Moreover, earlier work had already shown that uCTX-II has specifically strong associations with marker of bone metabolism as compared …

    View Full Text

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Copyright information:

    Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions