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GIMAP and Behçet disease: no association in the European population
  1. Lourdes Ortiz-Fernández1,
  2. Marta Conde-Jaldón1,
  3. José Raul García-Lozano1,
  4. Marco Antonio Montes-Cano1,
  5. Norberto Ortego-Centeno2,
  6. María Jesús Castillo-Palma3,
  7. Gerard Espinosa4,
  8. Genaro Graña-Gil5,
  9. Juan Sánchez-Bursón6,
  10. Miguel Angel González-Gay7,
  11. Ana Celia Barnosi-Marín8,
  12. Roser Solans9,
  13. Patricia Fanlo10,
  14. Mónica Rodríguez Carballeira11,
  15. Teresa Camps12,
  16. Santos Castañeda13,
  17. Javier Martín14,
  18. María Francisca González-Escribano1
  1. 1 Servicio de Inmunología, IBiS, H.U. Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain
  2. 2 Servicio de Medicina Interna, H. Clínico San Cecilio, Granada, Spain
  3. 3 Servicio de Medicina Interna, H. U. Virgen del Rocío, Sevilla, Spain
  4. 4 Servicio de Enfermedades Autoinmunes, H. Clinic, Barcelona, Spain
  5. 5 Servicio de Reumatología, CHU A Coruña, A Coruña, Spain
  6. 6 Servicio de Reumatología, H. de Valme, Sevilla, Spain
  7. 7 Servicio de Reumatología, H. Marques de Valdecilla, Santander, Spain
  8. 8 Servicio de Medicina Interna, H. Torrecárdenas, Almería, Spain
  9. 9 Servicio de Medicina Interna, H. Vall d'Hebron, Barcelona, Spain
  10. 10 Servicio de Medicina Interna, H. Virgen del Camino, Pamplona, Spain
  11. 11 Medicina Interna Unitat de Malalties Autoimmunes i Sistèmiques Hospital Universitari Mútua Terrassa, Terrassa, Spain
  12. 12 Servicio de Medicina Interna, H. Carlos Haya, Málaga, Spain
  13. 13 Servicio de Reumatología, H. de la Princesa, Madrid, Spain
  14. 14 Instituto de Parasitología y Biomedicina López Neyra, Granada, Spain
  1. Correspondence to Dr María Francisca González-Escribano, Servicio de Inmunología. HU Virgen del Rocío, Sevilla 41013, Spain; mariaf.gonzalez.sspa{at}

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Behçet disease (BD) is a multifactorial disorder with a highest prevalence among people with Mediterranean or Asian ancestry having association with HLA-B51 and other HLA and non-HLA loci.14 Very recently, one genome-wide association study (GWAS) identified the GIMAP locus, which encoded proteins involved in development of the T and B lymphocytes, as associated with the disease in the Asian populations.5 To investigate whether this association is replicated in Europeans, a total of 1086 (326 patients and 760 controls) Spanish individuals of European origin were genotyped after obtaining written informed consent and approval from the local ethical committees of all the institutions involved. Patients fulfilled the 1990 International Study Group classification criteria for Behçet’s disease,6 and the group was composed of 44.5% men with the following clinical features: 100% had oral ulcers, 63.6% genital ulcers, 58.7% uveitis, 48% arthritis, 20.2% vascular, 21.9% neurological and 19.2% gastrointestinal involvement. Regarding HLA association, in addition to B*51 (p<10−7, OR=4.11, 95% CI 2.79 to 6.06), B*57 was found to be risk factor in this cohort with an OR similar to that …

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  • Contributors MAM-C, JRG-L and MFG-E contributed to the conception and design of the research, analysis and interpretation of the data, draft and revision of the manuscript. LO-F and MC-J performed the experiments and analysed the data. The rest of the authors: NO-C, MJC-P, GE, GG-G, MAG-G, ACB-M, RS, PF, MRC, TC, SC, JS-B and JM contributed with samples and patient information. All authors read and approved the final version.

  • Funding This work was supported by Fondo de Investigaciones Sanitarias (10/1701), Fondos FEDER, Plan Andaluz de Investigación (CTS-0197 and CTS-180), Red Enfermedades Inflamatorias y Reumáticas and Consejería de Salud de la Junta de Andalucía (0260/08). LOF is the recipient of a fellowship (FI11/00547).

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval The local ethical committees of all the institutions involved.

  • Provenance and peer review Not commissioned; externally peer reviewed.