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Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence

Authors

  • Raewyn C Poulsen Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Anna C Watts Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Richard J Murphy Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Sarah J Snelling Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Andrew J Carr Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Philippa A Hulley Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Raewyn C Poulsen, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford OX3 7D, UK; raewyn.poulsen{at}ndorms.ox.ac.uk
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Citation

Poulsen RC, Watts AC, Murphy RJ, et al
Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence

Publication history

  • Accepted May 7, 2013
  • First published June 1, 2013.
Online issue publication 
June 06, 2014

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