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Contributors NNT experiments and writing; GdS experiments; JK reagents; PM writing.
Funding The study was supported in part by a grant from Novo Nordisk. NNT is supported by the IHU prometteur OPERA.
Competing interests Professor Miossec is a senior member of and supported by the Institut Universitaire de France.
Patient consent Obtained.
Ethics approval Ethics committee of the hospitals of Lyon.
Provenance and peer review Not commissioned; externally peer reviewed.
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