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Levels of soluble osteoclast-associated receptor (sOSCAR) in rheumatoid arthritis: link to disease severity and cardiovascular risk
  1. Ndiemé Ndongo-Thiam1,
  2. Geoffroy de Sallmard1,
  3. Jesper Kastrup2,
  4. Pierre Miossec1
  1. 1 Immunogenomics and Inflammation Unit and the Department of Clinical Immunology and Rheumatology, Hospices Civils de Lyon, EA 4130 University of Lyon 1, Lyon, France
  2. 2 Novo Nordisk A/S, Måløv, Denmark
  1. Correspondence to Professor P Miossec, Department of Clinical Immunology and Rheumatology, Hôpital Edouard Herriot, 69437 Lyon, Cedex 03, France; miossec{at}

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Osteoclast-associated receptor (OSCAR) is a costimulatory receptor implicated in osteoclast differentiation, with soluble and membranous forms.1 Its natural ligand appears to be collagen.2 Since the involvement of OSCAR in rheumatoid arthritis (RA) has been suggested,3 the present work assessed the levels of soluble OSCAR (sOSCAR) in RA and a possible link with disease severity and risk of cardiovascular events (CVE).4

sOSCAR was measured by indirect ELISA in 136 plasma samples from RA patients randomly selected from a large database according to the level of joint destruction at a 1:1 ratio and paired for sex and age. Clinical markers of disease severity and incidence of CVE are summarised in table 1. CVE (myocardial infarction, acute limb ischaemia, stoke, etc) were collected from the hospital chart and with a questionnaire to the patient and/or family physician. Only patients with CVE during the RA course were included. …

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  • Contributors NNT experiments and writing; GdS experiments; JK reagents; PM writing.

  • Funding The study was supported in part by a grant from Novo Nordisk. NNT is supported by the IHU prometteur OPERA.

  • Competing interests Professor Miossec is a senior member of and supported by the Institut Universitaire de France.

  • Patient consent Obtained.

  • Ethics approval Ethics committee of the hospitals of Lyon.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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