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We would like to thank Dr Zeng et al1 for the comments on our paper.2 Please see the point-to-point response as below:
As pointed out in the discussion of our paper, cross-sectional and case-control designs are not able to infer a causal relationship.2 The conclusion ‘low grade systemic inflammation may play a greater role in symptoms rather than radiographic changes in osteoarthritis (OA)’ does not necessarily imply a cause-effect relationship. It remains controversial whether inflammation is a cause for disease progression or a result of disease manifestation. …
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