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We read with interest the editorial by Ferraccioli and Houssiau proposing the specific targeting of long-lived plasma cells (PCs) in human lupus nephritis (LN).1 The authors present a cogent summary of experiments showing that long-lived PCs alone are sufficient to induce murine LN, and that targeting of PCs in these models is successful. However, we believe that clinical experience with the treatment of human SLE indicates that plasmablasts and short-lived PCs, recently derived from autoreactive B cells, are more important in the …
Competing interests Paul Emery and Edward M Vital have received honoraria and research grant support from Roche.
Provenance and peer review Not commissioned; internally peer reviewed.
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