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Lack of association between IL-15 genetic variants and progression of joint destruction in Japanese patients with rheumatoid arthritis
  1. Shinji Yoshida1,2,
  2. Katsunori Ikari1,
  3. Koichiro Yano1,
  4. Yoshiaki Toyama2,
  5. Atsuo Taniguchi1,
  6. Hisashi Yamanaka1,
  7. Shigeki Momohara1
  1. 1 Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
  2. 2 Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
  1. Correspondence to Katsunori Ikari, Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada, Shinjuku, Tokyo 162-0054, Japan; kikari{at}

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Recently, Knevel et al 1 reported that interleukin 15 (IL-15) genetic variants are associated with progression of joint destruction in patients with rheumatoid arthritis (RA) enrolled in a European multicohort study. IL-15 is a proinflammatory cytokine that is overexpressed in patients with RA. Overproduction of IL-15 is thought to induce T cell activation and proliferation, possibly contributing to the pathogenesis of RA.2 ,3 Some variants of genetic predisposition factors for RA are restricted to particular ethnic groups, revealing the presence of genetic heterogeneity.4 ,5 We investigated the associations between IL-15 genetic variants and progression of joint destruction in Japanese patients with RA.

We studied 865 patients with RA for whom Sharp/van der Heijde (SHS) scores of the hands were available at a disease duration of 5 years. DNA samples of the subjects were obtained from the Institute of Rheumatology Rheumatoid Arthritis (IORRA) cohort study DNA collection.6 All of the patients …

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  • Contributors SY, KY and KI performed the experiments and analysed the data; YT, AT, HY and SM contributed materials and SY and KI wrote the paper.

  • Funding The Japan Science and Technology Agency; The Japanese Ministry of Health, Labour and Welfare; The Japanese Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research.

  • Competing interests None.

  • Ethics approval Tokyo Women's Medical University genome ethics committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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